Comparing the unified protocol for transdiagnostic treatment of emotional disorders to prolonged exposure for the treatment of PTSD: Design of a non-inferiority randomized controlled trial

W Lau; K Chisholm; MW Gallagher; K Felmingham; K Murray; A Pearce; N Doyle; S Alexander; H O'Brien; A Putica; J Khatri; P Bockelmann; F Hosseiny; A Librado; M Notarianni; ML O'Donnell

Journal article

Comparing the unified protocol for transdiagnostic treatment of emotional disorders to prolonged exposure for the treatment of PTSD: Design of a non-inferiority randomized controlled trial

W Lau, K Chisholm, MW Gallagher, K Felmingham, K Murray, A Pearce, N Doyle, S Alexander, H O'Brien, A Putica, J Khatri, P Bockelmann, F Hosseiny, A Librado, M Notarianni, ML O'Donnell

Contemporary Clinical Trials Communications | ELSEVIER INC | Published : 2023

DOI: 10.1016/j.conctc.2023.101134

Abstract

Background: Prolonged Exposure (PE), a trauma-focused therapy, is one of the most efficacious treatments available for PTSD. However, many people with PTSD do not lose their diagnosis following delivery of PE. The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders is a non-trauma focused treatment that may offer an alternative treatment for PTSD. Methods: This paper describes the study protocol for IMPACT, an assessor-blinded randomized controlled trial that examines the non-inferiority of UP relative to PE for participants who meet DSM-5 criteria for current PTSD. One hundred and twenty adult participants with PTSD will be randomized to receive either 10 × 90-min ses..

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University of Melbourne Researchers

Kim Felmingham Author

Sophie Alexander Author

Hope O'Brien Author

Andrea Putica Author

Related Projects (1)

TRANSLATING SCIENCE INTO BETTER POSTTRAUMATIC MENTAL HEALTH

Trauma is responsible for a significant amount of mental health problems worldwide. Increasing disasters, violence, and war lead to much tra..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work is supported by a National Health and Medical Research Council Program Grant (#1073041) awarded to Meaghan O'Donnell, and by the Atlas Institute for Veterans and Families Canada. The funding sources have had no involvement in the study design, the collection, analysis and interpretation of data, the writing of this report, or the decision to submit this article for publication. The authors declare no competing interests.